Sodium Starch Glycollate

RAPIGEL (Sodium Starch Glycollate)

Sodium starch glycolate is manufactured by carboxymethylation of starch. The carboxymethylation process increases the ability of the starch to absorb water, making it a rapid disintegrant. Sodium starch glycolate is used as a disintegrant in capsule and tablet formulations. It is recommended to use in tablets prepared by either direct-compression or wet-granulation processes. Sodium starch glycolate has also been investigated for use as a suspending vehicle.

Tablets prepared with sodium starch glycolate have good storage properties. Sodium starch glycolate is stable although very hygroscopic, and should be stored in a well-closed container in order to protect it from wide variations of humidity and temperature, which may cause caking.


  • A super disintegrant meeting all pharmacopoeia requirements.
  • Disintegration occurs by rapid uptake of water followed by rapid and enormous swelling.

Applications of the Product

  • Suitable for a variety of tablet and capsule formulations
  • In higher concentrations, it can act as a dissolution enhancing agent
  • Disintegrant efficiency is unimpaired in presence of other hydrophobic excipients in the formulation